Pouzolzia zeylanica is a kind of medicinal plant which is generally cultivated in Mekong Delta region. It owns many bioactive compounds that are known to possess antioxidant, antimicrobial and anticarcinogenic properties. This study aimed to optimize additional carrier concentration for spray drying of Pouzolzia zeylanica extract. | 78 Nong Lam University, Ho Chi Minh City Optimization of maltodextrin and carrageenan gum concentration added in spray drying process of Pouzolzia zeylanica extract by response surface methodology Nguyen Duy Tan1 and Nguyen Minh Thuy2 1 An Giang University, Vietnam Can Tho University, Vietnam 2 ARTICLE INFO ABSTRACT Research Paper Pouzolzia zeylanica is a kind of medicinal plant which is generally cultivated in Mekong Delta region. It owns many bioactive compounds Recieved: January 02, 2018 that are known to possess antioxidant, antimicrobial and anticarcinogenic properties. This study aimed to optimize additional carrier Accepted: May 24, 2018 concentration for spray drying of Pouzolzia zeylanica extract. Response Surface Methodology (RSM) with central composite design (CCD) Keywords was applied for optimization and investigation of the influence of maltodextrin (5ö15%, w/v) and carrageenan gum (, w/v) Carragennan concentration on the physicochemical characteristics of spray dried Maltodextrin powder (bioactive compounds, moisture content as well as particle size Pouzolzia zeylanica distribution). The results showed that the optimum concentrations of Response Surface Methodology maltodextrin and carrageenan gum were w/v and w/v, Spray drying respectively. At these optimal conditions, the anthocyanin, flavonoid, polyphenol, tannin, moisture content and particle size of obtained spray dried powder were mg cyanidin-3-glycoside equivalents (CE)/100 g; Corresponding author mg quercetin equivalents (QE)/g; gallic acid equivalents (GAE)/g; mg tannic acid equivalents (TAE)/g, and µm, respectively. Nguyen Duy Tan Email: ndtan@ 1. Introduction tional products as beverage, instant tea, etc. In recent years, there has been growing interest in alternative therapies and the therapeutic use of natural products and in the last decade much attention has been shifted to search for phytochemicals of .