The objective of the this study is to provide an in vitro evidence for the potential hypoglycemic activity via inhibitory activity of the ethanolic and aqueous extracts from fruiting bodies of Pycnoporus sanguineus mushroom on α-amylase and α-glucosidase enzymes. Alpha-amylase and α-glucosidase inhibitory activities of ethanolic and aqueous extracts from P. sanguineus fruiting body were examined in a dose-response manner. | Hypoglycemic activity of fruiting body extracts from Pycnoporus sanguineus (L.: FR.) Murrill mushroom