Presentation article this study focus on developing new rice varieties which are salt tolerant combine with high yield potentials, high quality using Molecular Markers and convensional breeding. The Saltol QTL introgresion lines were developed and selected through generations from Vietnam popular rice variety AS996 using markers assisted backrossing (MABC). After three backcross generations, the selfing generations were developed. Conventional breeding were used to select the high yield, high quality lines. Screening for salinity tolerant were carried out to evaluate all the selected lines in the salt affected field and in greenhouse. The important agronomical traits evaluations concerning to high yield and resistances to biotic and abiotic stress (salt tolerance) were applied on the BC3F3 -BC3F6 generations for breeding purpose in several areas. A promissing new salt tolerant rice line with high yield potentials, high quality were received.