The objective of the study is to find out factors affecting the economic growth (GDP) of the 13 provinces/cities in the Mekong Delta. The study used secondary data from Statistical Yearbook of Statistical Office of 13 provinces cities in the Mekong Delta in the period of 2005 - 2014 . The study included 12 independent variables which impact on the ability of the local GDP method, which has turned "economic crisis" to a dummy variable.