Cytochrome P450s (CYPs) are one of the largest distributed enzymes, which catalyze more than 20 different reactions. At present, there has been an increasing realization of the power of P450 biocatalysts for the industrial synthesis of pharmaceuticals, agrochemicals, bulk chemicals, food ingredient, etc. | Mining cytochrome P450 genes through next generation sequencing and metagenomic analysis from Binh Chau hot spring