Some extracts of medicinal plants have been proven to be beneficial in treating a number of diseases for centuries such as treating diabetes, antioxidant, anti-inflammatory, antibacterial, etc. This study aimed to evaluate the effect of extracts from several herbal plants, such as Gymnema sylvestre, Stevia rebaudiana, Cinnamomum cassia, Zea may, Ocimum basilicumon on blood glucose level in streptozotocin (STZ) induced diabetic mice and to offer scientific proofs for the identified antihyperglycemic effect by investigating on mechanisms of the most effective extract. The results proved that diabetic mice treated with 70% ethanol extracts of Gymnema sylvestre leaves and Stevia rebaudiana leaves showed significant reduction of the blood glucose levels at a dose of 500 mg/kg body weight when compared to control (P | Study of antihyperglycaemic activity in Streptozotocin induced diabetic mice and antioxidant activities of medicinal plant extracts