Thrombin is the key enzyme of fibrin formation in the blood coagulation cascade. Thrombin is released by the hydrolysis of prothrombinase which is generated from factor Xa and factor Va in the presence of calcium ion and phospholipid. The inhibition of thrombin is of therapeutic interest in blood clot treatment. | Phenolic compounds from pamotrehydrophobic property of (R)-3 amidinophenylalanine inhibitors contributes to their inhibition constants with thrombin enzymema dilatatum growing in Lam Dong province
