To access the clinical and subclinical response of patients with pituitary adenoma by Gamma knife in Choray Hospital. Subjects and methods: A clinical, intervention study with no control group on 81 patients with definite diagnosis of recurrent or residual pituitary adenoma at Gamma Knife Unit, Choray Hospital from January 2012 to December 2016. Results: 23 patients with functioning tumours and 58 patients with nonfunctioning tumours. The average age was ± years, the youngest was 18, the oldest was 73 years old. Average volume of pituitary adenoma was 5, ± 2, mm3 . PLR increased in 15 cases and GH increased in 10 cases. After radiotherapy, 52 cases () responded to radiotherapy. The time when the tumour started to decrease in response to radiotherapy from the 12th month after radiotherapy was noted. | Assessment of clinical and subclinical response of patients with pituitary adenoma by gamma knife in choray hospital