The design of Serious Games for training in complex areas of expertise presents many difficulties related to trainers’ participation in the design phase, the formalization of scenarios describing highly complex situations, the limited number of scenarios in Serious Games due to their high costs, and the low re-use level of real-life scenarios. This study proposes functional and technical infrastructure with ARGILE (Architecture for Representations, Games, Interactions, and Learning among Experts) for design of Serious Games. We illustrate our solution applied to a project in the sustainable development field.