Epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cells lose cell-cell contacts and acquire expression of mesenchymal components and manifest a migratory phenotype. Recent studies indicated that EMT is involved in the development of keloids. | Metformin inhibits epithelial to mesenchymal transition of keloid fibroblasts via the HIF-1α/PKM2signaling pathway