Hes3 is a basic helix-loop-helix factor gene, which was found to be involved in neural cell differentiation. Expression and clinicopathological significance of Hes3 in non-small cell lung cancer was not clear. In this study, we used immunohistochemistry to examine Hes3 expression in normal human lung and non-small cell lung cancer tissues. | Hes3 enhances the malignant phenotype of lung cancer through upregulating cyclin D1, cyclin D3 and MMP7 expression