This study aimed to evaluate the effect of laser acupuncture combined with a diet-exercise intervention on features of the metabolic syndrome (MetS). Twenty-eight obese post-menopausal women were randomly distributed to the control and laser acupuncture group. The control group received the diet-exercise intervention and the study group received the same intervention and sessions of laser acupuncture, 3 times/week for 12 weeks. Anthropometric measurement, fasting blood glucose and insulin levels, homeostatic model assessment-insulin resistance (HOMA-IR), and lipid profile were assessed before and after the treatment course. Both groups showed a significant decrease in the anthropometric and metabolic parameters. However, laser acupuncture group showed a greater decrease in the waist (P = ) and hip (P = ) circumferences, cholesterol (P = ), and insulin levels (P = ) than the control group. These results suggest that laser acupuncture is a valuable approach that could be added to the diet-exercise intervention to correct features of the MetS. | Effect of laser acupuncture combined with a diet-exercise intervention on metabolic syndrome in post-menopausal women