Three sensitive methods were developed for simultaneous determination of Ezetimibe (EZB) and Atorvastatin calcium (ATVC) in binary mixtures. First derivative (D1 ) spectrophotometry was employed for simultaneous determination of EZB ( nm) and ATVC ( nm) with a mean percentage recovery of ± and ± , respectively. Linearity ranges were – lg mL1 and – lg mL1 , respectively. Isosbestic point (IS) spectrophotometry, in conjunction with second derivative (D2 ) spectrophotometry was employed for analysis of the same mixture. Total concentration was determined at IS, nm and nm over a concentration range of – lg mL1 and – lg mL1 , respectively. | Spectrophotometric and TLC-densitometric methods for the simultaneous determination of Ezetimibe and Atorvastatin calcium
