The goal of this in vitro study was to examine the effect of the alpha-2 adrenoceptor agonist dexmedetomidine on phenylephrine (alpha-1 adrenoceptor agonist)-induced contraction in isolated rat aortae and to elucidate the associated cellular mechanisms, with a particular focus on alpha-1 adrenoceptor antagonism. | Dexmedetomidine inhibits phenylephrine-induced contractions via alpha-1 adrenoceptor blockade and nitric oxide release in isolated rat aortae