Triprolidine hydrochloride (TpCl) ion-selective carbon paste electrodes were constructed using Tp-TPB/Tp-CoN and Tp-TPB/Tp-PTA as ion-exchangers. The two electrodes revealed Nernstian responses with slopes of and mV decade1 at 25 C in the ranges 6 • 106 – 1 • 102 and 2 • 105 –1 • 102 M for Tp-TPB/Tp-CoN and Tp-TPB/Tp-PTA, respectively. The potentials of these electrodes were independent of pH in the ranges of – and –, and detection limits were 6 • 106 and 1 • 105 M for Tp-TPB/Tp-CoN and Tp-TPB/Tp-PTA, respectively. The electrodes showed a very good selectivity for TpCl with respect to a large number of inorganic cations and compounds. The standard addition, potentiometric titration methods and FIA were applied to the determination of TpCl in pure solutions and pharmaceutical preparations. The results obtained were in close agreement with those found by the official method. The mean recovery values were and with low coefficient of variation values of , and in pure solutions, and with coefficient of variation values of , and for Actifed tablet and Actifed syrup, respectively, using the Tp-TPB/Tp-CoN electrode, and , and with coefficient of variation values of and for Actifed tablet and Actifed syrup, respectively, using the Tp-TPB/Tp-PTA electrode. | Mixed ion-exchanger chemically modified carbon paste ion-selective electrodes for determination of triprolidine hydrochloride
