This paper investigates the applicability and challenges of GIScience in the context of mountain geography with ample evidences and observations from the mountain specific publications, empirical research findings and reports. The contextual explanation of mountain geography, mountain specific problems, scientific concerns about the mountain geography, advances in GIScience, the role of GIScience for sustainable development, challenges on application of GIScience in the contexts of mountains are the points of discussion. Finally, conclusion has been made with some specific action oriented recommendations.