To evaluate safety of measles and rubella combined vaccine. Subjects and methods: Randomized, controlled and single-blind clinical trial study was conducted on 756 people aged 1 to 45 years old in Hanam and Hoabinh provinces. Results: Incidence of adverse events within the 30-minute and the 28-day follow-up in the two study groups were and ; and . Conclusions: Measles and rubella combined vaccine was safely used on volunteers and not significantly different from the control group. | Safety of measles and rubella combined vaccine manufacturing by POLYVAC in Vietnamese volunteers