To assess of qualities of free opioid anesthesia, the effects on circulation, respiration and its side effects. Subjects and methods: Prospective free opioid anesthesia study, 30 patients were treated by laparoscopic cholecystectomy at 103 Millitary Hospital from May, 2018 to February, 2019. | Study of free opioid anesthesia for laparoscopic cholecystectomy