One of the earliest neuropathological events in Alzheimer’s disease is accumulation of astrocytes at sites of Aβ1-42 depositions. Our results indicate that Aβ1-42 toxic peptide increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in primary culture. | Astrocytes protect neurons from Aβ1-42 peptideinduced neurotoxicity increasing TFAM and PGC-1 and decreasing PPAR-γ and SIRT-1