Present study was carried out to evaluate toxic effect of cadmium chloride at 15, 50 and 100 ppm in drinking water for 28 days on liver, kidney, heart and intestine in male rats. Twenty-four male albino rats (270 to 340 g, 4 weeks of age) were randomly divided in to 4 groups having 6 animals in each group. The animals of control group received distilled water throughout the experimental period, while rats of other three groups received either 15, 50 or100 ppm of CdCl2 in drinking water for consecutive 28 days. Haematological and biochemical parameters, histopathological evaluation and status of oxidative stress markers were observed at the end of study. Alterations in ALT, AST, AKP and BUN of rats of all three toxic groups were dose dependant. SOD activity (U/mL) was significantly increased (p | Oxidative stress mediated dose-dependent pathophysiological alterations in liver, kidney, heart and intestine of rats exposed to different levels of Cadmium Chloride
