Hepatitis B virus (HBV) infection is a serious global health problem affecting two billion people worldwide, and 400 million people suffer from chronic HBV infection. In India Hepatitis B surface antigen (HBsAg) is used as the sole marker to check safety of blood transfusion as well as antenatal screening of mothers to prevent transmission of infection to newborn. Despite mandatory screening for HBsAg by Enzyme Linked Immuno Sorbent Assay (ELISA) or similar tests, transfusion-associated HBV (TAHBV) continues to be a major problem in India, more so in patients receiving repeated transfusions. Present study was undertaken to detect the presence of occult hepatitis B (OBI) infections in normal healthy adult population which go undetected by routine HBsAg screen and to ascertain whether HBsAg test alone is enough as a screening test to prevent hepatitis transmission to recipient after blood transfusion and to newborn from infected mother. A total of 1421 serum samples collected from HBsAg-negative healthy adults (18 to 50 years of age) were tested for the presence of antibodies to hepatitis B core antigen (anti-HBc). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs. | HBs antigen Elisa as a marker for blood transfusion safety and antenatal screening: Is it enough?
