Rice is one of the three major food crops in the world. It is the staple food for most of the people of South-East Asia. Rice productivity fluctuates significantly from region to region; season to season due to biotic and abiotic stress. Sheath blight is one of the major biotic constraints in rice cultivation. It is caused by Rhizoctonia solani Kuhn. This disease can cause yield reduction between 20-50% depending on the severity of infection. Several genotypes reported for sheath blight resistance but none of the genotypes were found with absolute resistance. Sheath blight resistance is controlled by polygenes or quantitative trait loci (QTLs) each with small effect. Pyramiding of such QTLs is expected to increase resistance to sheath blight in the cultivars. Genetic engineering of crops with plant pathogenesis-related (PR) genes may give a promising and long-lasting solution for sheath blight disease management.