The present investigation was carried out for appraisal of antioxidative strategies in the erythrocytes of Marwari sheep during moderate, hot and cold ambiences. In each ambience, animals were categorized as male, female, 6-12 months, 12-18 months and 18- 24 months. Haemolysates were prepared to determine enzymes of antioxidative strategies. Enzymes of antioxidative strategies included glucose-6-phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH). Effect of extreme hot and cold ambiences was observed on both indicators of antioxidative strategies in the erythrocytes of Marwari sheep. The mean values of LDH in erythrocytes were significantly (p≤) higher during hot and cold ambiences as compared to moderate mean value. The mean values were significantly (p≤) higher in male animals in all the ambiences for G6PDH and was higher in females for LDH. The mean values of G6PDH in erythrocytes were significantly (p≤) lower during hot ambience and significantly (p≤) higher during cold ambience as compared to moderate mean value. Age effect showed a significant (p≤) increase in the mean values of all the indicators being highest in the sheep of 18-24 months of age. | Appraisal of antioxidative strategies in the erythrocytes of Marwari sheep during extreme ambiences