Nine Propionibacterium acnes (P. acnes) strains resistant to both clindamycin and erythromycin were selected to investigate the inhibitory ability of extracts and isolated compounds from leaves of Cassia grandis to P. acnes. Ethyl acetate extract inhibited all P. acnes strains, with an aseptic ring diameter of 15-25 mm at a concentration of 200 mg/mL and a MIC value of 30 mg/mL. | Inhibitory ability of extracts and compounds from leaves of cassia grandis to propionibacterium acnes AGU International Journal of Sciences – 2019, Vol. 7 (4), 1 – 11 INHIBITORY ABILITY OF EXTRACTS AND COMPOUNDS FROM LEAVES OF CASSIA GRANDIS TO PROPIONIBACTERIUM ACNES Ngo Quoc Luan1,2, Phung Thi Yen Thanh2, Tran Nhan Dung3, Huynh Van Ba4 1 Vietnam Academy of Science and Technology 2 School of Education, Can Tho University 3 Biotechnology Research & Development Institute, Can Tho University 4 Can Tho Dermatology Hospital Information: ABSTRACT Received: 070/8/2018 Nine Propionibacterium acnes (P. acnes) strains resistant to both Accepted: 03/01/2019 clindamycin and erythromycin were selected to investigate the inhibitory Published: 11/2019 ability of extracts and isolated compounds from leaves of Cassia grandis Keywords: to P. acnes. Ethyl acetate extract inhibited all P. acnes strains, with an P. acnes, Cassia grandis , aseptic ring diameter of 15-25 mm at a concentration of 200 mg/mL and a quercitrin MIC value of 30 mg/mL. The fraction H:E 1:1 showed the strongest antibacterial activity in the three investigated fractions (H:E 1:1, H:E 1:3 and E 100%) with an aseptic ring diameter of mm at a concentration of 200 mg/mL (tested on three strongest resistance strains) and the MIC value was determined to be mg/mL. In three pure compounds isolated from ethyl acetate extract, quercitrin strongest inhibited for P. acnes with a MIC value of mg/mL. 1. INTRODUCTION al., 2014; Fu Y. et al., 2007) but no remarkable Propionibacterium acnes (P. acnes) is published announcement shows potential considered to be an important cause of acne. applications. However, the treatment with synthetic Traditionally, it is said that leaves of Cassia antibiotics in the long term also causes many grandis can cure a number of skin diseases unwanted side effects. On the other hand, the such as .
