Plants are always under the radar of the pathogen, with their different means of infecting them. And conventional methods of managing plant diseases are showing transient effectiveness, as they never last long. Introduction of next generation sequencing, has provided with whole lot of information regarding host and pathogen. It analyses a large number of pathogen isolates and host varieties rapidly at lower cost. In this host pathogen dynamics, effector molecules play a very crucial role. Genomic approaches like RNA analysis, microarrays have unveiled the role of effectors in plant host responses and have advanced our knowledge in terms of pathogen’s potential virulence factor, pathogenicity island, information related to R genes and its cloning, effector diversity of pathogen and global monitoring of pathogen. Through this paper different aspects of genomics as well as role of effectors in plant immunity are reviewed.