Seven non-descript cats presented with signs of pyothorax were included for the study. Affected cats showed respiratory distress, oral breathing, extended head/neck, abducted elbow, dyspnoea and fever. Muffled heart sounds were appreciated on auscultation. Thoracocentesis was done at 7th intercostal space. Haematology revealed leukocytosis with neutrophilia. Radiography and echocardiography confirmed the pyothorax. Staphylococcus sp and/or Streptococcus sp were isolated from pleural fluid. All the affected cats were treated with amoxicillin+cloxacillin and furosemide. All the animals showed remarkable recovery.