Effect of FYM and fly ash application on yield, content, uptake and quality of safedmusali in Inceptisols was investigated in field experiment carried out on clayey soil at Nagarjun Medicinal Plants Garden, Dr. Panjabrao Deshmukh Krishi Vidyapeeth, Akola (.). There were three levels of FYM and four levels of fly ash with three replications tried in Factorial randomised block design. The results obtained in the present investigation showed that, the number of leaves per plant and leaf area of Safed musli were non significantly influenced due to application of Fly ash. No significant effect of FYM application was also noticed on number of leaves. However, leaf area was significantly influenced with the application of FYM upto 10 t FYM ha-1 . The fresh as well as dry root yield was significantly recorded highest with the application of 20 t FYM ha-1 . The highest safed musli root yield was also recorded with the application of fly ash 15 t ha-1 . However, it was at par with 10 t and 5 t ha-1 Fly ash applications. The content and uptake of nutrients, were also significantly influenced with the application of FYM and fly ash. The saponin content and yield and protein content of Safed musli roots were significantly increased with 20 t FYM ha-1 . The significantly highest saponin content and yield and protein content also recorded with 15 t Fly ash ha-1 . However, it was at par with 10 and 5 t fly ash levels. | Consequence of fym and fly ash application on yield, nutrient uptake, and quality of safed musli grown on Inceptisols