Among all the gastrointestinal nematodes belonging to family Trichostrongylidae, Haemonchus contortus is the most prevalent and highly pathogenic nematode causing severe loss to small ruminant production system. Parasite causes alterations in various physiological parameters with disturbances in haemato-biochemical blood profile. Experiment was conducted in eighteen (n=18) non-descript sheep that were randomly divided into two groups, infected (Group-A) and (Group-B) the negative control. Group- A animals were infected with 10,000 L3 of . Larvae for the infective dose were obtained through coproculture of faeces of previously infected sheep. Animals were stall fed and were maintained separately in the animal shed to prevent infection. Haematological (Hb, PCV, TLC, DLC) and biochemical parameters (Total protein, albumin, globulin) were monitored at weekly intervals in both the groups. Results of the present study concluded that infection with led to disturbance in haemopoietic system that led to alterations in blood haemo-biochemical profile. Mean Hb level in case of infected group (Group-A) declined from ± to ± at 5th week post infection (PI). Similarly, PCV dropped from ± to ±. Mean Hb and PCV values for negative control (Group-B) remained within normal range . ± and ±. Leucocyte count started declining from third week PI in Group-A. By 28 days PI neutrophila and eosinophilia was observed in Group-A. Decline in albumin levels was more pronounced in infected group and reached up to ± at 3rd week post infection. No changes were observed in serum albumin levels throughout experiment in negative control group. Albumin to globulin ratio decreased significantly in group A on 3 rd, 4th and 5th week post infection as compared to negative control group. | Haemato-biochemical alterations in sheep due to experimentally induced Haemonchus contortus infection
