Community acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) has been recognised as one of the important pathogen in head and neck infections. These infections include tonsillitis, thyroiditis, sinusitis, periorbital cellulitis, otitis, retropharyngeal abscess, cervical lymphadenitis and wounds of the neck. This review illustrates the growing prevalence of CA-MRSA, and the current therapeutic approaches to head and neck infections caused by this bacterium. Treatment of head and neck infections associated with CA-MRSA includes drainage and debridement, as well as administration of local and systemic antibiotics that provide potential coverage against these organisms and against polymicrobial infection (aerobic and anaerobic) that may be present in such wounds.