Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and longterm disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even more in regions with lower level of perinatal care. The only established therapy to improve outcome in these infants is therapeutic hypothermia. | Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): Study protocol of a blinded randomized placebocontrolled parallel group multicenter trial for superiority (phase III)
