This review article represents copper poisoning in farm animals with special emphasis on pathogenesis, clinical findings, diagnostic and preventive approaches. Diagnosis of any poisoning is very difficult and can’t be based on any single observation. keeping in view regarding difficulties in diagnosis, it must be combination of history, clinical signs, pathological findings, tests results, response to therapy and most important, the judgement of a toxicologist. Copper is an integral part of many important enzymes involved in number of vital biological processes like metalloprotein enzymes, metalloporphyrin enzymes. Copper is required, but is also highly toxic. Most of the cases of poisoning remain undiagnosed because of the lack of sophisticated techniques at veterinary hospitals. | Copper poisoning in farm animals: Diagnostic and preventive approaches