Hepatitis B virus (HBV) is one of the most important agent causing transfusion transmitted infections in multitranfused patients. HBV-DNA is a concern for transmission from transfusion or transplantation in serologically negative blood for HBV ., occult hepatitis B (OHB). The aim of this study is to find out the prevalence of HBV infection in multitransfusd patients including OHB infections. The present study was conducted in 200 multitransfused patients attending the haematology/thalassemia OPD. Blood sample were collected and tested for HBsAg, Anti HBs, Anti HBc and HBV DNA by DNA PCR. Out of the total 200 patients, total prevalence of HBV amounted to 28% including various markers of HBV infection was HBsAg only 3(), Anti HBc only 49() and Anti HBc plus HBs Ag 4(2%). Out of 49 AntiHBc positive samples 3() patients were positive for HBV DNA. Newer methods such as HBV DNA PCR, Anti HBc should be introduced in the routine screening of blood donors to reduce the window period and to prevent transmission. Emphasis on complete hepatitis B vaccination and regular follow up for anti HBs titre, providing booster doses for those in need should be implemented. | Seroprevalence of hepatitis B virus in multitransfused patients with special reference to occult hepatitis B virus infection
