By WHO forecasts, a further increase in the prevalence and mortality of COPD among people of working age is predicted, due to uncontrolled environmental pollution, a tobacco pandemic, an increase in the level of allergens and a genetic predisposition. In chronization and progression of COPD, there is a violation of cellular and humoral immunity, production of pro-inflammatory cytokines of phagocytic cell activity that contribute to the persistence of the inflammatory process in the lungs. Therefore, the study of the state of intestinal microflora in patients with COPD and the timely correction of impaired microbiocinosis is an important task that needs to be studied. Patients with COPD have a chronic inflammatory process in the bronchopulmonary system, accompanied by inhibition of the functional activity of neutrophils, which complicates the formation of humoral immunity and leads to a persistent course of the disease with frequent exacerbations. The revealed violations of COPD associated with intestinal dysbacteriosis indicate pronounced manifestations of secondary immunodeficiency. The obtained data allow us to recommend bacteriological and immunological examination of patients with COPD to identify immunological deficiencies with concomitant intestinal dysbiosis for the purpose of complex treatment with the use of immunocorrecting and probiotics.
