Due to broad range of effects, corticosteroids are frequently used in veterinary practice. Wide ranges of biological effects are mediated via different dose and potency of different glucocorticoids. Intensive short-term glucocorticoid use can decrease the morbidity and mortality of potentially fatal conditions but in long run their use can lead to immunosuppression, duodenal ulceration, pancreatitis, adrenal atrophy, hyperadrenocorticism, glucose intolerance and many more diseases. Multitude of adverse effects distinct from pharmacologic or physiologic responses has also been associated with corticosteroid use. The dose should be tapered and changed to alternate-day therapy as soon as possible, but caution should be taken not to allow recurrence of disease. The underlying disease must also be directly addressed as corticosteroids most often only suppress symptoms without treating the disease.
