Single CRP in combination with RNSOS can be used for rapid identification of neonates with sepsis due to high sensitivity () but cannot exclude those without sepsis due to low specificity (). Serial CRP done 12hrs apart can be used to exclude non-cases. This study demonstrated very high levels of resistance to the first-line antibiotics. | Management of neonatal sepsis at Muhimbili National Hospital in Dar es Salaam: Diagnostic accuracy of C – reactive protein and newborn scale of sepsis and antimicrobial resistance pattern of etiological bacteria