Honey is defined as a natural sweet substance which is produced from the floral nectar by honeybees. Honey is well-known for its antimicrobial activities and it has been reported to have antibacterial effect to about 60 species of bacteria and antifungal properties as well. Honey has been used to inhibit these bacteria as well as to prevent and treat skin and other infections. Honey as a tropical antibacterial agent for treatment of infected wounds. The natural ingredients of honey show different activities against various microorganisms. Honey has an increasing effect on the levels of anti-oxidants, iron and rare elements in blood. The antimicrobial property is also based on UMF of that honey taken showed that honey had a more pronounced inhibitory effect () on Gram negative bacteria (Pseudomonas aeruginosa, Enterobacter spp., Klebsiella) in comparison to commonly used antimicrobial agents. To analyse the establishment activity of different honey (Coorg honey, Kashmir Herbal honey, Natural Kashmir honey, Dabur honey and Manuka honey) on various organisms like Acinetobacter, Coagulase Negative Staphylococcus (CONS), Methicillin resistant Coagulase Negative Staphylococcus (MRCONS), Methicillin Sensitive Staphylococcus aureus (MSSA), Methicillin resistant Staphylococcus aureus (MRSA), Enterococcus, Klebsiella, E. coli, ATCC Staphylococcus aureus, Pseudomonas With various concentration (10%, 20%, 50% ). Among all the brands of honey tested Manuka honey was effective against ever against all the organisms tested at 50% concentration. Similarly Dabur Honey was effective against all organisms at 50%. In conclusion, though Manuka honey is the best for treating microorganisms, it is not affordable to low socioeconomic people, because of its high cost. Still Dabur Honey can be an alternative topical agent to treat burns wound infections which are cost effective. Honey exhibits antimicrobial property against gram negative and few gram positive organisms. | To study the antimicrobial properties of honey on common microorganisms