From water fraction of the whole plant of Piper betle, three compounds including thymidine (1), adenosine (2), and 1,2-di-O-β-glucopyranosyl-4- allylbenzene (3) were isolated. Their chemical structures were elucidated by analyses of their NMR spectral data and comparison with those reported in the literature. Among three isolated compounds, this is the first report the isolation of 1,2-di-O-β-glucopyranosyl-4-allylbenzene from P. betle. | Investigation on chemical constituent of water fraction of Piper betle L