The experiment was undertaken to evaluate the effect of zincoxide nanoparticles (ZnO NPs) on antioxidant status of methotrexate intoxicated Wistar albino rats. Seventy-two rats of 180 to 200g weight were equally divided into six groups. MTX was used at the rate of 5mg/kg intraperitoneally for three consecutive days to induce toxicity and ZnO NPs was used @ of 50mg/kg through oral gavage for 45 days. Antioxidant status of rats was evaluated by estimating products of oxidative injury (MDA) and endogenous antioxidant enzymes (CAT, SOD and GPx) in the liver on 7th, 21st and 45th days of experiment. | Effect of zinc oxide nanoparticles (ZnO NP) on antioxidant status of methotrexate (MTX) induced toxicity in wistar albino rats
