Pseudomonas aeruginosa are associated with large number of identified infections. Rise in multidrug resistance among clinical isolates. A total of 342 specimens were collected from swabs (pus, blood, burn, exudate, tip and scalp specimen) and obtained during 12 months (January 2017- December 2017). The Majority of P. aeruginosa were isolated from swab specimens accounted217 (99%). The male to female were 241 (70%) to 101 (30%) respectively. P. aeurginosa showed a high susceptibility rate toward colistin, followed by ciprofloxacin while the high resistant rate toward Augmentin followed by Doxacillin. | Antibiotic susceptibility and resistant pattern of isolates of pseudomonas aeruginosa recovered from infected swabs, abscess, burn, medical tips and blood from patients at 4 geographical locations in libya (Al- Bayda, Shahat, Derna and Benghazi)