Fever of unknown origin (FUO) can be defined as a body temperature higher than °C on several occasions over more than 3 weeks, the diagnosis of which remains uncertain after 1 week of evaluation. Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system with a wide range of clinical manifestations. | Acute disseminated encephalomyelitis presenting as fever of unknown origin: Case report