A study was carried out to induce the cyclicity in anoestrus Murrah buffaloes with different hormonal preparations and biochemical changes in blood occurring during anoestrus were also studied. The present investigation was conducted during summer season (April–May) and the buffaloes were randomly divided into two groups of 12 animals each, viz., Group I (n=12; CIDR + PMSG 500 . + hCG 1500 .) animals treated with CIDR protocol and Group II (n=12; Hydroxyprogesterone caproate 500 mg + Estradiol valerate 5mg + PMSG 500 ) animals treated with Progesterone and Estradiol (P and E) combination protocol. | Management of Anoestrus murrah buffaloes using two different hormonal approaches