Resistance to antimicrobial agents among clinically important pathogens in the community and environment has compromised therapy and requires constant monitoring of emerging pathogens. Current investigation was aimed at determining the antimicrobial resistance pattern in bacteria isolated from public water body near a hospital and also from two fish farms which used the same water for aquaculture. Of 105 isolates, maximum number of isolates belonged to the Enterobacter spp. | Occurrence and distribution of multiple antibiotic resistance bacteria of public health significance in backwaters and aquaculture farm