Significant advances of groundwater flow modeling have been driven by the demand to predict regional impacts of human inferences on groundwater systems and associated environment. Large scale transient groundwater models have been built to analyze regional flow systems, to simulate water budget components changes, and to optimize groundwater development scenarios. The main intent of the paper is to present a comprehensive review on application MODFLOW package for ground water management and development. Specific methodologies for regional groundwater flow modeling are descried.