Sufficient attention is required for middle-aged males before and during exposure to long-term ADV therapy, regardless of nationality. The clinical picture, laboratory and radiograph alterations are important clues for those patients and are usually characterized by polyarthralgia, renal tubular dysfunction and mineralization defects. | Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: A comparative study of Chinese and foreign case series