Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1, 4-disubstituted piperidines with simple molecular structures were evaluated in this study. | Structurally simple synthetic 1, 4- disubstituted piperidines with high selectivity for resistant Plasmodium falciparum