Biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) tablets are formulated with gastroretentive ER drug delivery technology that has been associated with clinically meaningful food effects in other approved products. | Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/ extended-release hydrocodone bitartrate/ acetaminophen (MNK-155) under fed and fasted conditions: Two randomized open-label trials