Acyclovir has been widely used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus (VZV). The common adverse effects of this drug include nausea, diarrhea, headache, dizziness and mental changes. The immune thrombocytopenia induced by acyclovir is rare. | A rare case report of acyclovir-induced immune thrombocytopenia with tongue hematomas as the first sign, and a literature review