The present investigation was carried out to study the effect of certain uterine immunomodulators on microbial status of endometritic cows. A total number of fifty endometritic cows selected after screening were allotted randomly into five equal groups (n=10). The Group I, II, III, IV Cows were intrauterinely administered with 100µg of E. coli LPS (single dose), 500 mg of oyster glycogen (OG) (single dose), 1000 mg Enrofloxacin (once daily for 3days) and 250 ×106 lymphocytes (single dose) each reconstituted with 30 milliliter of PBS. | Effect of certain immunotherapeutics on microbial status of endometritic cows