Endometrial histopathology was studied in 16 postpartum dairy cows. Endometrial biopsy was taken from the all experimental animals, to study the histopathological changes of the uterine endometrium. 8 cows in group I (n=8) on day 2 postpartum and were treated with an intramuscular injection of 5 mg methyl ergometrine maleate. All the cows in group I were inserted with Controlled Internal Drug Release device (CIDR) on day 45-55 postpartum intra-vaginally. Whereas 8 cows in group II (n=8) were selected at day 35-50 postpartum and supplemented with TANUVAS mineral mixture and treated with ovsynch treatment. In group I cows on day 10 postpartum, showed involution process, with mild neutrophilic and mononuclear infiltration. | Uterine endometrial regeneration and conception rate following oestrus induction with CIDR and ovsynch treatment in postpartum dairy cows