A number of old and new pathogen has emerged or re-emerged in past 30 years. Increase in interaction at the interface of human and animals plays a crucial role in transmission of these zoonotic agents at the interface. Burgeoning human population, increased global communication, habitat destruction, bush meat consumption, intensification of animal farming. Along with emergence of antimicrobial resistance and increased incidence food borne infections are important public health implications in which human-animal interface plays a definite role. Despite initiatives taken by Indian government to consolidate inter-sectorial collaboration, still recent policies still lacks one health approach.